Carcinogenicity is a toxicity that causes cancer in body. Generally carcinogenicity test requires long time (usually 2 years), currently only in vivo test methods are established. Usually the test uses mice or rats, exposing them to a compound. And the variable to be observed is existence of cancer. PreADMET predicts the result from its model, which is built from the data of NTP (National Toxicology Program) and US FDA, which are the results of the in vivo carcinogenicity tests of mice and rats for 2 years.
|negative||Clear evidence of carcinogenic activity||negative prediction|
|positive||No evidence of carcinogenic activity||positive prediction|