In the pharmaceutical, cosmetic and agrochemical fields, it is important to predict the skin permeability rate for a crucial parameter for the transdermal delivery of drugs and for the risk assessment of all chemicals that come into contact with the skin either accidentally or by design. In PreADMET can predict in vitro data on human for skin permeability.
PreADMET predicts in vitro skin permeability and the result value is given as logKp. Kp (cm/hour) is defined as:
where Km is distribution coefficient between stratum corneum and vehicle, and D is average diffusion coefficient (cm2/h), and h is thickness of skin (cm).
[ Singh,S. et al. Med. Res. Rev. 1993, 13, 569. ]